2,2-Dimethyl-4,5-diaryl-3(2H)furanone derivatives as selective cyclo-oxygenase-2 inhibitors

S S Shin; M S Noh; Y J Byun; J K Choi; J Y Kim; K M Lim; J Y Ha; J K Kim; C H Lee; S Chung

doi:10.1016/s0960-894x(00)00634-x

2,2-Dimethyl-4,5-diaryl-3(2H)furanone derivatives as selective cyclo-oxygenase-2 inhibitors

Bioorg Med Chem Lett. 2001 Jan 22;11(2):165-8. doi: 10.1016/s0960-894x(00)00634-x.

Authors

S S Shin¹, M S Noh, Y J Byun, J K Choi, J Y Kim, K M Lim, J Y Ha, J K Kim, C H Lee, S Chung

Affiliation

¹ Drug Discovery, Pacific Corporation R&D Center, Yongin-si, Kyounggi-do, South Korea.

PMID: 11206450
DOI: 10.1016/s0960-894x(00)00634-x

Abstract

A series of 2,2-dimethyl-5-[4-(methylsulfonyl)phenyl]-4-phenyl-3(2H)furanones was prepared and evaluated for their ability to inhibit cyclo-oxygenase-2 (COX-2).

MeSH terms

Animals
Arthritis, Experimental / drug therapy
Combinatorial Chemistry Techniques
Cyclooxygenase 1
Cyclooxygenase 2
Cyclooxygenase 2 Inhibitors
Cyclooxygenase Inhibitors / chemical synthesis
Cyclooxygenase Inhibitors / chemistry
Cyclooxygenase Inhibitors / pharmacology
Disease Models, Animal
Edema / chemically induced
Edema / drug therapy
Foot Diseases / chemically induced
Foot Diseases / drug therapy
Furans / chemical synthesis
Furans / chemistry
Furans / pharmacology*
Inhibitory Concentration 50
Isoenzymes / antagonists & inhibitors*
Membrane Proteins
Prostaglandin-Endoperoxide Synthases
Rats
Rats, Sprague-Dawley
Structure-Activity Relationship

Substances

Cyclooxygenase 2 Inhibitors
Cyclooxygenase Inhibitors
Furans
Isoenzymes
Membrane Proteins
Cyclooxygenase 1
Cyclooxygenase 2
Prostaglandin-Endoperoxide Synthases
Ptgs1 protein, rat